# Juicebox (Web)

We'll start with the lightweight version of Juicebox available on the web. Open a browser and type [`https://aidenlab.org/juicebox`](https://aidenlab.org/juicebox) or click the hyperlink.

Juicebox on the Web is run via client side JavaScript. Any hic file can be loaded from a URL – and in particular, .hic files uploaded to Dropbox, GEO, Google Drive, Amazon S3, or any web server can be streamed!

{% hint style="success" %}
You can even browse 3D Genomics Hi-C maps on your mobile phone!
{% endhint %}

Juicebox on the Web makes it easy to browse maps side-by-side and to share exactly what you’re looking at with collaborators. The core functionality of browsing contact maps together with epigenetic marks is the same as Juicebox Desktop.

## Loading Maps

![](/files/-M7i1B245RN7aDMEz3hz)

1. Click `Load Map → ENCODE` 
2. Choose the first map, the combined replicate  map `MboI primary+replicate GM12878`

![](/files/-M7hEjkko1_1hgLPMmlF)

The genome-wide view will load for the .hic file.

![](/files/-M7DFWdPi4AqiFrnBCXM)

## Zooming In

Let's zoom in on chromosome 17. To select the chromosome from the genome-wide view, you can:

* Click on the three bar "hamburger" icon in the right top corner, then select the chromosome under the dropdown menu
* Click on the region of the Hi-C map corresponding to chromosome 17
* Click on the numbered chromosome axis label

![](/files/-M7DKC72TKOGfk9KRME6)

This will load the chromosome-wide view.

![](/files/-M7DGWtQ2k8733LqSBI_)

Let's change the `Norm` (Normalization) to `Balanced`. This balances the map to account for types of experimental bias in the data.

![](/files/-M7DGqPLfgmh39soMAU_)

There are several ways to zoom in a Hi-C map. Let's zoom into the region around 69.4 MB to 72.3 MB. You can use one of the following methods:

* Slide the resolution dropdown to 5 KB. Use your mouse to pan until your position is roughly 69.4 MB to 72.3 MB. 

![](/files/-M7DHPPo08jbrvLJ0I3S)

* Type in `17:69,357,606-72,237,605 17:69,352,606-72,232,605` in the location text panel and press the enter key. Go to 5 KB if necessary. 

![](/files/-M7hGNM4W7PL-XKU5tX0)

* Hold down the Alt key (Option key on Macs) and draw a box that encompasses 69.4 MB to 72.3 MB. Repeat as necessary and use the mouse to pan until you find the right location.

![](/files/-M7DK67eL9MRRLz3H7Wg)

* Zoom in further by clicking; the heat map will be centered at the point you click.
* Use pinch zoom on a mobile device and pan as needed until you're at the target location.
* Type in your gene of interest in the location text box to jump to the location.

You should see the following region:

![](/files/-M7DKoJ8R90F9SKSW8Q2)


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